Chemical Name/IUPAC:2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-oneTechnical Data
Product Name: MK-1775 (AZD-1775)
Chemical Formula: C27H32N8O2
Molecular Weight: 500.59
CAS#: 955365-80-7
Appearance: Solid powder
Purity: > 99% by HPLC
Solubility: Soluble in DMSO
Storage: Room temperature for months, or -20oC for 3 yearsDescription MK-1775 (AZD-1775) is a WEE1 inhibitor. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.
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Jacob Taylor - 2024-03-03
From the fast shipping to the high-quality product, everything was perfect. Customer service was also exceptional. Will definitely be back.